The following is the cast of voice artists for the characters in Afterworld.
| Andrew Ableson | Charles Keyes Subu |
| Kirk Baily | Ted Murphy |
| Aaron Bennett | Doug Heidland Homeland Agent #2 |
| David Berman | Scientist |
| Andy Black | Toll Gate Man |
| Jon Bruno | Jack Hastings Graves Andrew Helm |
| Boris Chernin | Thaddeus Gerson |
| Simon Chernin | Harold Keeler Josh Benson |
| Jeffrey Combs | Glen Wilkins Battery Bill Edward Hanley |
| Tonya Cornelisse | Amy |
| Roark Critchlow | Russell Shoemaker |
| Rosarios Dawson | Officer Delondre Baines |
| Matt Dente | Larry Fishman Cpt. Johnny Orstrom |
| Frederic Durand | Canadian Man |
| Patrick Falls | Nick Gardner |
| Brent Friedman | Shoemaker's father |
| Lynn Evans | Gwen |
| Jackie Hahn | Andrea Gardner |
| Nicole Hanson | Janelle Shoemaker Marla Baker Liam's mother |
| Charlie Hartsock | Arnold Doctor Canton Donald Powell III |
| Daric Hughes | Horsemen #1 |
| George Henry | George |
| Bryan Irving | Security Guard |
| Kang-Min | Phil Young |
| Phil LaMarr | Col. Nixon |
| Jonathan LaPaglia | John Daggert (a.k.a. JD) |
| Adam Lazarre-White | Hola |
| Yuri Lowenthal | Mr. Tanaka Frank |
| Shelton Mack | Addae |
| Annika Marks | Ellen Murphy |
| Michael Medico | Travis Jay |
| Mauricio Mendoza | Salazar |
| Tricia Munford | Alice Sivley |
| Parry Anne Norton | Lulu |
| Tara Platt | Kizzy Shoemaker |
| Ivor Pyres | Sanjay Pathak |
| Ben Raab | Horsemen |
| Caleb Rapoport | Barrett Keane The Berserker |
| Chuck Rapoport | E. W. Hunter Gavin |
| John Alexander Reed | Liam's father Horsemen #2 |
| Zeke Rippy | Bryson Fox Sam Rhoades |
| Jackson Rogow | Horsemen #3 |
| Richard Sanchez | Cartel Guard Homeland Agent #1 Timothy |
| Graham Sibley | Arlin Cale |
| Josh Stern | Jeff Kettleman |
| Tracie Thoms | Nurse Thomas |
| Gwendolen Twist | Jason Baker Feral Boy |
| Gustavo Vazquez | Luther Gates |
| Paul Webster | Eli The Contrarian |
| Stephanie Wiand | Joan Diane Shop Owner |
| Pam Whitman | Flashlight Sue |
See also[]
- Characters - a list of characters in Afterworld
- Crew - the people involved in the making of Afterworld